EBOOK ECM: PREDICTIVE MOLECULAR PATHOLOGY IN SOLID TUMORS - 2026

Precision medicine has transformed the clinical management of patients with solid tumors. In this context, numerous clinically relevant predictive biomarkers have been implemented in clinical practice to guide the management of solid tumors based on molecular profiling of tumor cells.
The evolving landscape of molecular biomarkers paved the way for the widespread adoption of Next Generation Sequencing (NGS) platforms in the clinical management of patients with solid tumors. Traditional techniques such as immunohistochemistry (IHC) and fluorescent in-situ hybridization (FISH) have been progressively integrated with molecular systems based on polymerase chain reaction (PCR) and NGS plat-forms in molecular profiling of diagnostic specimens.1 As a result, the number of clinically approved bi-omarkers has rapidly increased. Furthermore, the clinical use of comprehensive NGS panels has revealed a wide range of promising biomarkers for diagnosis, prognosis, and therapeutic decision-making of solid tu-mors.
A major challenge is the lack of standardized pre-analytical procedures, which affects the success rate of interpretable molecular results when applying molecular techniques. Liquid biopsy has emerged as an integrative biological matrix that supports molecular testing when ‘gold standard’ tissue specimens are insufficient for molecular analysis. The term ‘liquid biopsy’ encompasses various biological fluids – e.g., blood, urine, plasma, saliva, CFS – containing analytes such as circulating tumor cells (CTCs), microRNAs (miR-NAs), circulating free DNA (cfDNA), and extracellular vesicles (EVs), which can be isolated using specific technical platforms. Given these critical issues, integrating diagnostic approaches based on harmonized pre-analytical, analytical, and data reporting strategies should be encouraged for stratifying patients who could benefit from targeted therapies.
To address these emerging challenges, diagnostic strategies require optimized protocols tailored to pre-analytical and analytical issues encountered in diagnostic clinical setting.
Here, the authors want to comprehensively evaluate the predictive biomarkers routinely approved for various solid tumors, focusing on technical solutions, molecular aspects, and clinical outcomes.

 EBOOK 

. INTRODUCTION
. PREDICTIVE MOLECULAR PATHOLOGY: LUNG CANCER
. PREDICTIVE MOLECULAR PATHOLOGY: COLORECTAL CANCER
. PREDICTIVE MOLECULAR PATHOLOGY: MELANOMA
. PREDICTIVE MOLECULAR PATHOLOGY: BREAST CANCER 
. PREDICTIVE MOLECULAR PATHOLOGY: ENDOMETRIAL CANCER
. PREDICTIVE MOLECULAR PATHOLOGY: EPITHELIAL OVARIAN CANCER
. PREDICTIVE MOLECULAR PATHOLOGY: CENTRAL NERVOUS SYSTEM TUMORS
. REFERENCES

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Questionario (obbligatoriamente a risposta multipla e doppia randomizzazione)
da compilare ENTRO LE ORE 24.00 DEL 14/07/2027

Attenzione: la nuova normativa ministeriale in vigore dal 01/07/2019 prevede che:

• in caso il discente non superi il test di valutazione dovrà ripetere il percorso formativo dall'inizio
• numero massimo di tentativi a diposizione: 5
• soglia di superamento: 75% delle risposte corrette